Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220 Rabbit pAb (APR30247N) APR30247N

Product info:

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]

Alternative names:

HDAC4/HDAC5/HDAC9

Species reactivity:

Human

Host:

Rabbit

Cellular localisation:

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Isotype:

IgG

Immunogen:

A phospho specific peptide corresponding to residues surrounding S246 of human HDAC4

Positive control:

293, 293+EGF

AA Sequence:

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Purification:

Affinity purification

Molecular weight:

Calculated MW: 57-65kDa/97-122kDa Observed MW: 125kDa/140kDa

Form:

Liquid

Applications:

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Dilution:

WB 1:500 - 1:1000 IHC 1:50 - 1:100

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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