Product info:

The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Alternative names:

E330016A19Rik; cGAS

Species reactivity:

Human, Rat

Host:

Rabbit

Cellular localisation:

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Isotype:

IgG

Immunogen:

A phospho synthetic peptide corresponding to residues surrounding S420 of Mouse CGAS.

Positive control:

293T, C6

AA Sequence:

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Purification:

Affinity purification

Molecular weight:

Observed MW: 62KDa

Form:

Liquid

Applications:

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Dilution:

WB 1:500 - 1:2000

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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