Phospho-CDK4-T172 Rabbit pAb (AMR01014N) AMR01014N

Product info:

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Alternative names:

CDK4; CMM3; PSK-J3

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Cellular localisation:

Cytoplasm, Membrane, Nucleus

Isotype:

IgG

Immunogen:

A synthetic phosphorylated peptide around T172 of human CDK4 (NP_000066.1).

Positive control:

NIH/3T3

AA Sequence:

ALTPV

Purification:

Affinity purification

Molecular weight:

Calculated MW: 20kDa/33kDa Observed MW: 33KDa

Form:

Liquid

Applications:

WB (Homo sapiens, Capra hircus, Mus musculus)

Dilution:

WB 1:500 - 1:2000

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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