Phospho-eIF2α-S51 Rabbit pAb (AMR00902N) AMR00902N

Product info:

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

Alternative names:

EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A; EIF2S1

Species reactivity:

Human, Rat

Host:

Rabbit

Cellular localisation:

Cytoplasmic granule

Isotype:

IgG

Immunogen:

A phospho specific peptide corresponding to residues surrounding S51 of human EIF2S1

Positive control:

HeLa, C6

AA Sequence:

Email info@sobekbio.com for sequence

Purification:

Affinity purification

Molecular weight:

Calculated MW: 36kDa Observed MW: 38KDa

Form:

Liquid

Applications:

WB (Raw264.7, HeLa, HepG2, Homo sapiens)

Dilution:

WB 1:500 - 1:2000

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com