Phospho-MET-Y1349 Rabbit pAb (AMR00829N) AMR00829N

Product info:

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.

Alternative names:

MET; AUTS9; DFNB97; HGFR; RCCP2; c-Met

Species reactivity:

Human

Host:

Rabbit

Cellular localisation:

Membrane, Secreted, Single-pass type I membrane protein

Isotype:

IgG

Immunogen:

A synthetic phosphorylated peptide around Y1349 of human MET (NP_000236.2).

Positive control:

HeLa

AA Sequence:

EHYVH

Purification:

Affinity purification

Molecular weight:

Calculated MW: 85kDa/155kDa/157kDa Observed MW: 160kDa

Form:

Liquid

Applications:

WB (Mus musculus)

Dilution:

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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