Phospho-PKCalpha-S226 Rabbit pAb (AMR00991N) AMR00991N

Product info:

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

Alternative names:

PRKCA; AAG6; PKC-alpha; PKCA; PRKACA; PKC alpha

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Cellular localisation:

Cell membrane, Cytoplasm, Mitochondrion membrane, Nucleus, Peripheral membrane protein

Isotype:

IgG

Immunogen:

A synthetic phosphorylated peptide around S226 of human PKCalpha (NP_002728.2).

Positive control:

293

AA Sequence:

NESFT

Purification:

Affinity purification

Molecular weight:

Calculated MW: 76kDa Observed MW: 80kDa

Form:

Liquid

Applications:

WB (Mus musculus)

Dilution:

WB 1:500 - 1:2000

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

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