Phospho-RB-S608 Rabbit pAb (AMR00999N) AMR00999N

Product info:

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Alternative names:

OSRC; PPP1R130; RB; p105-Rb; pRb; pp110; RB1; Rb

Species reactivity:

Human

Host:

Rabbit

Cellular localisation:

Nucleus

Isotype:

IgG

Immunogen:

A synthetic phosphorylated peptide around S608 of human RB (NP_000312.2).

Positive control:

Jurkat

AA Sequence:

YLSPV

Purification:

Affinity purification

Molecular weight:

Calculated MW: 106kDa Observed MW: 110kDa

Form:

Liquid

Applications:

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Dilution:

WB 1:500 - 1:2000

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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