Phospho-ALOX5-S271 Rabbit pAb (AMR01001N) AMR01001N

Product info:

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names:

ALOX5; 5-LO; 5-LOX; 5LPG; LOG5

Species reactivity:

Human

Host:

Rabbit

Cellular localisation:

Cytoplasm, Nucleus matrix, Nucleus membrane, Peripheral membrane protein

Isotype:

IgG

Immunogen:

A synthetic phosphorylated peptide around S271 of human ALOX5 (NP_000689.1).

Positive control:

HT-29+EGF, HT-29+PMA

AA Sequence:

QLSLE

Purification:

Affinity purification

Molecular weight:

Calculated MW: 56kDa/61kDa/71kDa/74kDa/77kDa Observed MW: 78kDa

Form:

Liquid

Applications:

Request info at info@sobekbio.com

Dilution:

WB 1:500 - 1:2000

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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