Phospho-DNMT1-pS714 Rabbit pAb (AMR00779N) AMR00779N

Product info:

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.

Alternative names:

ADCADN; AIM; CXXC9; DNMT; HSN1E; MCMT; m.HsaI; DNMT1

Species reactivity:

Human

Host:

Rabbit

Cellular localisation:

Nucleus

Isotype:

IgG

Immunogen:

A synthetic phosphorylated peptide around S714 of human Phospho-DNMT1-pS714 (NP_001370.1).

Positive control:

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AA Sequence:

MPSPK

Purification:

Affinity purification

Molecular weight:

Calculated MW: 144kDa/183kDa/184kDa Observed MW: Refer to Figures

Form:

Liquid

Applications:

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Dilution:

WB 1:500 - 1:2000 IF 1:50 - 1:200

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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