Phospho-INPP5D-Y1020 Rabbit pAb (AMR01061N) AMR01061N

Product info:

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.

Alternative names:

INPP5D; SHIP; SHIP-1; SHIP1; SIP-145; hp51CN; p150Ship

Species reactivity:

Human

Host:

Rabbit

Cellular localisation:

Cytoplasm, Membrane, Peripheral membrane protein

Isotype:

IgG

Immunogen:

A synthetic phosphorylated peptide around Y1020 of human INPP5D (NP_001017915.1).

Positive control:

Raji

AA Sequence:

ENPLY

Purification:

Affinity purification

Molecular weight:

Calculated MW: 109kDa/133kDa Observed MW: 145KDa

Form:

Liquid

Applications:

Request info at info@sobekbio.com

Dilution:

WB 1:500 - 1:2000

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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