ELK Biotechnology

ELK biotechnology is a high-tech biological company focusing on the development and production of immune products and molecular biology products.
Their products cover around 8.000+ ELISA kits, 11.000+ antibodies, and multiple kinds of genome extraction reagents, molecular biology reagents and cell experiment related products.
ELK Biotechnology is involved in immunochemistry, tumor research, neurobiology, cell cycle, signal transduction among other fields.
Their products have strict R&D and quality inspection processes, for this reason each product has complete R&D, production and quality inspection records.

While developing, ELK Biotechnology always implements the concept of environmental protection in their production processes, and always takes scientific development and environmental protection as their company's mission. In line with the belief of providing scientists with the most cutting-edge and most cost-effective research tools, ELK Biotechnology will continue to devote themselves to providing high-quality scientific research products for scientific researchers and contributing to the development of human life sciences.

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Huntingtin Rabbit pAb ES5728

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Specifications

size	50µl / 100µl

Background:

Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13. kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10. kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression.

Alternative names:

HTT; HD; IT15; Huntingtin; Huntington disease protein; HD protein

Clonality:

Polyclonal

Reactivity:

Human,Mouse,Rat

Source:

Rabbit

Isotype:

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Immunogen:

Synthesized peptide derived from human Huntingtin around the non-phosphorylation site of S421.

Concentration:

1mg/ml

Applications:

IHC, ELISA

Recommende dilutions:

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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