Background:
CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
Alternative names:
T-cell surface glycoprotein CD8 alpha chain,CD8A,T-lymphocyte differentiation antigen T8/Leu-2,MAL
Description:
Antibody for flow cytometry
Species reactivity:
Human
Host:
Mouse
Isotype:
Mouse IgG2a, κ
Concentration:
Request info at info@sobekbio.com
Buffer:
PBS with 0.05% Proclin300, 1% BSA
Conjugation:
PE
Applications:
FCM
Storage:
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
More info:
Email: info@sobekbio.com
Orders:
Email: orders@sobekbio.com
