Background:

Binds to transcription factors via its WW domain.,The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes.,Functions as a transcriptional coactivator.,PTM:Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export.,Contains 1 WW domain.,subcellular location:Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ.,subunit:Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP.,tissue specificity:Highly expressed in kidney, heart, placenta and lung.,

Classification:

Primary antibody

Alternative names:

WW domain-containing transcription regulator protein 1 ;Transcriptional coactivator with PDZ-binding motif

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from part region of human protein

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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