Background:

The protein encoded by AXL (AXL receptor tyrosine kinase) is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). AXL may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of AXL.

Classification:

Primary antibody

Alternative names:

AXL; UFO; Tyrosine-protein kinase receptor UFO; AXL oncogene

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from Axl . at AA range: 630-710

Concentration:

1 mg/ml

Molecular weight:

97437

Applications:

WB, ELISA

Storage:

-20°C for one year

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