Background:

TRIP4 (thyroid hormone receptor interactor 4) encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in TRIP4 are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1).

Classification:

Primary antibody

Alternative names:

Achaete-scute homolog 1 (ASH-1) (hASH1) (Class A basic helix-loop-helix protein 46) (bHLHa46)

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthetic peptide from human protein at AA range: 190-236

Concentration:

1 mg/ml

Molecular weight:

66146

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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