Background:

CHRNA3 encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. CHRNA3 encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein (cholinergic receptor nicotinic alpha 3 subunit) is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.

Classification:

Primary antibody

Alternative names:

CHRNA3; NACHRA3; Neuronal acetylcholine receptor subunit alpha-3

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human AChRalpha3. AA range:90-139

Concentration:

1 mg/ml

Molecular weight:

57310

Applications:

WB, ELISA

Storage:

-20°C for one year

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