Background:

Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. AAK1 encodes a member (AP2 associated kinase 1) of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Classification:

Primary antibody

Alternative names:

AAK1; KIAA1048; AP2-associated protein kinase 1; Adaptor-associated kinase 1

Species reactivity:

Human;Mouse;Rat;Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human AAK1. AA range:271-320

Concentration:

1 mg/ml

Molecular weight:

93578

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for one year

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